Region 6 is comprised of Harris and 12 surrounding counties. With 7.5 million residents, including 1.9 million children, the region comprises 25 percent of the Texas population. Using data made available by the Texas Department of Family and Protective Services (DFPS) and the University of Texas System, this 2021 community profile provides insights about the children and families within the region that are involved with, or at risk of involvement with, the child welfare system. This profile is a point-in-time snapshot reflecting data available at the time of publication1 , and it is intended to serve as an information source for individuals, organizations, and collaboratives interested in understanding the region and responding to its needs.